Updated September 2011

Grants Awarded for the 2009-2010 Award Year

Experimental assessment of laser-assisted
cryosurgery: Ex-vivo and in-vivo studies
Guillermo Aguilar
Department of Mechanical Engineering,
UC Riverside

Identification of glioma susceptibility genes
in the dog
Danika Bannasch
Department of Population Health and Reproduction,
UC Davis

Modulation of the breast tumor inflammatory response
by HoxD10
Nancy Boudreau
Department of Surgery, UC San Francisco

UHRF1 protein mediates maintenance of DNA- and
chromatin-based epigenetic memory
Frederic Chedin
Section of Molecular and Cellular Biology,
UC Davis

Hepatocyte Nox proteins in the pathogenesis of
hepatocellular carcinoma
Jinah Choi
Program of Biological Sciences, UC Merced

The molecular basis of cell cycle control by taranis,
the Drosophila ortholog of human TRIP-Br oncoproteins
Michael Cleary
Program of Biological Sciences, UC Merced

Determining the role of Pygopus 2 protein in
Wnt-induced tumorigenesis and stem cell expansion
Xing Dai
Department of Biological Chemistry, UC Irvine

Regulated expression of the Sall2 transcription factor
in human colon cancer
David Donner
Department of Surgery, UC San Francisco

Control of connective tissue remodeling by
the conserved DNA repair factor XAB2
Alison Frand
Department of Biological Chemistry,
UC Los Angeles

Total synthesis of welwistatin, a potent anticancer agent
Neil Garg
Department of Chemistry and Biochemistry,
UC Los Angeles

Targeting embryonic and cancer stem cells with
cell cycle inhibitors
Andrei Goga
Department of Medicine, UC San Francisco

Induction of cell death in T-cell acute lymphoblastic
leukemia by modulation of calcium signalling
Yousang Gwack
Department of Physiology, UC Los Angeles

Systems analysis of oral cancer
Shen Hu
Division of Oral Biology and Medicine, UC Los Angeles

Regulation of p53 by CSN5 in human cancers
Lan Huang
Department of Developmental and Cell Biology, UC Irvine

Image-directed tissue analysis of breast cancer
Bonnie Joe
Department of Radiology and Biomedical Imaging,
UC San Francisco

Polymer conjugated peptide mediated immunotherapeutic agents
Andrea Kasko
Department of Bioengineering, UC Los Angeles

Mechanisms that control entry into mitosis
Douglas Kellogg
Department of Molecular, Cell and Developmental Biology,
UC Santa Cruz

Exploring re-replication as a novel source of
chromosome instability
Joachim Li
Department of Microbiology and Immunology,
UC San Francisco

Defining the molecular mechanisms underlying
cancer initiation
William Lowry
Department of Molecular, Cell and Developmental Biology,
UC Los Angeles

Role of growth signaling pathways in cancer
Julian Martinez
Department of Human Genetics, UC Los Angeles

Dissecting chromatin modifications that interact to
regulate cell growth and response to DNA damage
Lorraine Pillus
Section of Molecular Biology, UC San Diego

Epigenetic immunosensitization of central
nervous system tumors with
the histone deacetylase inhibitor, LBH589,
for adoptive transfer immunotherapy
Robert Prins
Department of Neurosurgery, UC Los Angeles

Evaluating the role of PI3-K/PTEN in
teratocarcinoma formation and pluripotency
of human embryonic stem cells
April Pyle
Department of Microbiology, Immunology and Molecular Genetics, UC Los Angeles

Mechanism and inhibition of the human de novo DNA
methyltransferase DNMT3A
Norbert Reich
Department of Chemistry and Biochemistry, UC Santa Barbara

Characterization of DEPDC1 family proteins in G protein signaling
Lesilee Rose
Section of Molecular and Cellular Biology, UC Davis

Genetic analysis of aberrant protein synthesis
control downstream of PI3K signaling in
prostate cancer
Davide Ruggero
Department of Urology, UC San Francisco

Elucidating the RNA targets and activities of
the onco-fetal RNA binding protein KOC
in pancreatic ductal adenocarcinoma
Jeremy Sanford
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz

Using matrix metalloproteinase gene and
protein expression profiles to determine
the risk of central neck lymph node metastases
in papillary thyroid cancer
Wen Shen
Department of Surgery, UC San Francisco

Characterization of novel mechanisms for
KASH proteins at the outer nuclear membrane
Daniel Starr
Section of Molecular and Cellular Biology, UC Davis

Computational tools to identify pathways perturbed
in cancer
Joshua Stuart
Department of Biomolecular Engineering, UC Santa Cruz

Elasto-optical tomography for breast cancer imaging
Lizhi Sun
Department of Civil and Environmental Engineering, UC Irvine

Role of the Wnt signaling pathway for
tumor progression in adenoid cystic carcinoma
of the salivary gland
Osamu Tetsu
Department of Otolaryngology, UC San Francisco

Antibody-CpG conjugates for the treatment of lymphoma
John Timmerman
Department of Medicine, UC Los Angeles

Impact of chronic stress and behavioral coping
on mammary tumor development
in a mouse model of ErbB2-positive breast cancer
Brian Trainor
Department of Psychology, UC Davis

Effects of systemic aging environment
on adult stem cells and their implications in cancer
Shyni Varghese
Department of Bioengineering, UC San Diego

Transcriptional targets of Notch signaling
in lung cancer
Thiennu Vu
Department of Medicine, UC San Francisco

Measuring mechanical forces generated
following Notch ligand-receptor interactions
using optical tweezers
Geraldine Weinmaster
Department of Biological Chemistry, UC Los Angeles

Regulation of DNA repair by SUMOylation
Kyoko Yokomori
Department of Biological Chemistry, UC Irvine

P-TEFb as a novel therapeutic target for
treating cancer
Qiang Zhou
Department of Molecular and Cell Biology, UC Berkeley