Updated September 2009

Grants Awarded for the 2008-2009 Award Year

Regulation of the yeast S phase checkpoint through
a conserved Zn++ finger domain
in the replication protein Dbf4
Jeff Bachant
Department of Cell Biology and Neuroscience,
UC Riverside

FDG-PET/CT and molecular markers for early prediction of efficacy in advanced NSCLC patients treated with the EGFR-TKI erlotinib
Ramsey Badawi
Department of Radiology, UC Davis

Induction of anti-tumor immunity by specific innate immune receptors
Gregory Barton
Department of Molecular and Cell Biology, UC Berkeley

Identification of dopamine regulated molecular effectors involved in the genesis of pituitary tumors
Emiliana Borrelli
Department of Microbiology and Molecular Genetics,
UC Irvine

Targeting EMP2 in endometrial cancer
Jonathan Braun
Department of Pathology and Laboratory Medicine,
UC Los Angeles

Epigenetic regulation of SOCS1 in glioblastoma multiforme
Nicholas Cacalano
Department of Radiation Oncology, UC Los Angeles

Role of p65Nrf1 transcription factor in tumor suppression
Jefferson Chan
Department of Pathology and Laboratory Medicine,
UC Irvine

Replication and pathogenesis of XMRV; a new human retrovirus associated with prostate cancer
JSamson Chow
Department of Molecular and Medical Pharmacology,
UC Los Angeles

Determining the role of Bmi1 in tumorigenesis and generation of cancer stem cells
Amander Clark
Department of Molecular, Cell and Developmental Biology,
UC Los Angeles

Genome-wide assessment of DNA methylation in pancreatic adenocarcinoma
David Dawson
Department of Pathology and Laboratory Medicine,
UC Los Angeles

Intersection of NF-kB and fibroblast growth factor receptor signaling pathways
Daniel Donoghue
Department of Chemistry and Biochemistry,
UC San Diego

Predicting treatment response of soft tissue sarcomas to neoadjuvant therapy by imaging proliferation with a FLT-PET/CT scan: A pilot study
Frederick Eilber
Department of Surgery, UC Los Angeles

A small animal model for replication by a human retrovirus implicated in prostate cancer
Hung Fan
Department of Molecular Biology and Biochemistry,
UC Irvine

A newly discovered PI4P signaling pathway as a novel cancer therapy target
Seth Field
Department of Medicine, UC San Diego

Control of leukemia cell metabolism by the PI3K/AKT pathway
David Fruman
Department of Molecular Biology and Biochemistry,
UC Irvine

Developing systems-based methodologies for constructing context-specific versions of the Bcr-Abl and Src signaling network
Thomas Graeber
Department of Molecular and Medical Pharmacology,
UC Los Angeles

Continuous-flow hyperpolarization of 13C NMR signal of pyruvate to enable dynamic detection of tumor treatment effects through pyruvate to lactate metabolic turnover
Song-I Han
Department of Chemistry and Biochemistry,
UC Santa Barbara

Dendritic cell targeted vaccination
Stephen Hedrick
Department of Cellular and Molecular Medicine,
UC San Diego

Upconversion nanoparticles for photodynamic cancer therapy
Yu Huang
Department of Materials Science and Engineering,
UC Los Angeles

Estrogen promotes angiogenesis: Impact for breast cancer
Christopher Hughes
Department of Molecular Biology and Biochemistry,
UC Irvine

Regulation of inflammation by epidermal caspase-8
Colin Jamora
Section of Cell and Developmental Biology,
UC San Diego

A novel role for the kinase complex Bur1/2 in pre-mRNA splicing and the molecular basis of cancer
Tracy Johnson
Section of Molecular Biology, UC San Diego

Metabolite-dependent cell cycle arrest in cancer cells
Peter Kaiser
Department of Biological Chemistry, UC Irvine

Chromatin insulators in human cells
Rohinton Kamakaka
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz

Design and synthesis of potent anti-cancer agents
Yoshihisa Kobayashi
Department of Chemistry and Biochemistry,
UC San Diego

Defining meningioma stem cells:
The key to developing more representative model systems
Anita Lal
Department of Neurological Surgery, UC San Francisco

Susceptibility to ovarian cancer is related to biotransformation capacity
Ulrike Luderer
Department of Medicine, UC Irvine

Elucidation of a potential role of a histone methyltransferase subunit in coordinating TGN traffic and gene expression
Dzwokai Ma
Neuroscience Research Institute, UC Santa Barbara

A peek into focal adhesion mechanotransduction: The key initial step in cell migration and metastasis
Mohammad Mofrad
Department of Bioengineering, UC Berkeley

Protease activated gene transfer for local and targeted delivery to cancer cells
Tatiana Segura
Department of Chemical and Biomolecular Engineering,
UC Los Angeles

Screens for novel regulators of the TOR complex 2 signaling pathway
Kazuhiro Shiozaki
Section of Microbiology, UC Davis

Microtubule acetylation and cancer
Christine Suetterlin
Department of Developmental and Cell Biology,
UC Irvine

Investigating the mechanisms of the sensitization effect of gold nanoparticles in radiation treatment of cancer cells
Andrew Vaughan
Department of Radiation Oncology, UC Davis

Selective modulation of glucocorticoid receptor action
Jen-Chywan Wang
Department of Nutritional Sciences and Toxicology,
UC Berkeley