Updated September 2008

Grants Awarded for the 2006-2007 Award Year

Mechanism of selective apoptotic death of glioma cells induced by the loss of function of transcription factor ATF5
James Angelastro
Department of Molecular Biosciences, UC Davis

Structure-function studies and therapeutic discovery for human CTP synthetase
Enoch Baldwin
Section of Molecular and Cellular Biology, UC Davis

Galectin-9 mediates dendritic cell responses to urate, and endogenous "danger signal"
Linda Baum
Department of Pathology and Laboratory Medicine, UC Los Angeles

Steroid and xenobiotic receptor mediated steroid homeostasis
Bruce Blumberg
Department of Developmental and Cell Biology, UC Irvine

Structural development of polyoma viruses in association to cellular/nuclear entry and tumorigenesis
Holland Cheng
Section of Molecular and Cellular Biology, UC Davis

Molecular dissection of a novel meiotic checkpoint
Abby Dernburg
Department of Molecular and Cell Biology, UC Berkeley

Effect of antiretroviral therapy on the pathogenesis and histology of AIDS-related lymphoma
Catherine Diamond
Department of Medicine, UC Irvine

Distinct roles of Mad3 and Nmyc1 in medulloblastoma
Elva Diaz
Department of Medical Pharmacology and Toxicology, UC Davis

The role of EphB receptor signaling in melanoma progression
Iryna Ethell
Division of Biomedical Sciences, UC Riverside

Mechanical contributions to leukostasis in leukemia
Daniel Fletcher
Division of Biomedical Sciences, UC Riverside

Dissecting the mechanisms of ephrin-A reverse signaling in cellular adhesion
David Feldheim
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz

The role of circulating progenitor epithelial cells in the prevention of squamous metaplasia
Brigitte Gomperts
Department of Pediatrics, UC Los Angeles

Novel compounds to inhibit urokinase plasminogen activator (uPA) pathway in maligant glial brain tumors
Fredric Gorin
Department of Neurology, UC Davis

Developing magnetic tweezers to investigate mitotic chromosome architecture and dynamics
Rebecca Heald
Department of Molecular and Cell Biology, UC Berkeley

Coordinated control of pre-mRNA splicing and chromatin modification and the molecular basis of cancer
Tracy Johnson
Section of Molecular Biology, UC San Diego

High-throughput screen for chemical inhibitors of spliceosomes
Melissa Jurica
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz

A common functional genetic polymorphism, folate status, DNA methylation, and risk of breast cancer
Deborah Kado
Department of Medicine, UC Los Angeles

Mitotic fidelity in colonic villi of APCmin/+ mice
Kenneth Kaplan
Section of Molecular and Cellular Biology, UC Davis

Madindoline A: A model compound for antagonizing gp130-dependent growth of prostate cancer
John Krolewski
Department of Pathology and Laboratory Medicine, UC Irvine

Control of cellular structure in glioblastoma multiforme
Sanjay Kumar
Department of Bioengineering, UC Berkeley

Visualizing lipid raft associated ERBB2 and its role in herceptin function and resistance
Ralf Landgraf
Department of Medicine, UC Los Angeles

Microcoil NMR experiments for the identification of oligosaccharide binding motifs
Cynthia Larive
Department of Chemistry, UC Riverside

IGFBP-3 as an anti-angiogenic agent
Kuk-Wha Lee
Department of Pediatrics, UC Los Angeles

Molecular analysis of the inheritance of transcriptional silencing
Joachim Li
Department of Microbiology and Immunology, UC San Francisco

MRI brain tumor characterization by detecting and amplifying spatial variations in magnetic susceptibility and chemical exchange rate
Yung-Ya Lin
Department of Chemistry and Biochemistry, UC Los Angeles

MEF2C as a transcriptional regulator of normal and malignant hematopoietic cells
Hanna Mikkola
Department of Molecular, Cell and Developmental Biology, UC Los Angeles

Functional analysis of cell-cycle regulated Cdc13p phosphorylation in S. cerevisiae
Constance Nugent
Department of Cell Biology and Neuroscience, UC Riverside

Defining the ER stress-induced death pathway
Scott Oakes
Department of Pathology, UC San Francisco

Development of multi-functional nanoparticles for cancer research
Mihri Ozkan
Department of Electrical Engineering, UC Riverside

Development of the UPR as a drug target for multiple myeloma
Feroz Papa
Department of Medicine, UC San Francisco

Synthesis and study of phosphatidyl inositol-3-kinase inhibitors
Michael Pirrung
Department of Chemistry, UC Riverside

Characterization of a novel member of the tubulin superfamily
Joseph Pogliano>
Section of Molecular Biology, UC San Diego

Identification of PINCH-dependent fibroblast functions promoting cancer invasion and metastasis
Ann Rearden
Department of Pathology, UC San Diego

Microfabricated biosensors for monitoring energy metabolism in cancer cells
Alexander Revzin
Department of Biomedical Engineering, UC Davis

Induction of anti-tumor immunity by a humanized antibody against prostate stem cell antigen
Michael Roth
Department of Medicine, UC Los Angeles

Sin1 - A Molecular link between TOR and the stress MAPK cascade
Kazuhiro Shiozaki
Section of Microbiology, UC Davis

Regulation of bipolar spindle formation by the Golgi protein GRASP65
Christine Suetterlin
Department of Developmental and Cell Biology, UC Irvine

The role of DNA damage checkpoints during the metaphase to anaphase transition
William Sullivan
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz

Synthesis of new anticancer natural products
Emmanuel Theodorakis
Department of Chemistry and Biochemistry, UC San Diego

Oxidative injury in liver carcinogenesis
Natalie Torok
Department of Internal Medicine, UC Davis

Proteomic and metabolic discovery of biofluid markers of kidney cancer
Robert Weiss
Department of Internal Medicine, UC Davis

Sulforaphane: Preclinical analysis of its potential for treatment of cancer in combination therapy
Leslie Wilson
Department of Molecular, Cellular and Developmental Biology, UC Santa Barbara

The in vivo roles of epithelial-mesenchymal transition in skin tumor progression
Jing Yang
Department of Pharmacology, UC San Diego