Grants Awarded for the 2005-2006 Award Year

New approaches to the synthesis of anti-cancer γ-lactam proteasome inhibitors
Jeffrey Bode
Department of Chemistry and Biochemistry, UC Santa Barbara

DNA replication asymmetry and sister chromatid bias in meiotic recombination initiation in Saccharomyces cerevisiae
Sean Burgess
Section of Molecular and Cellular Biology, UC Davis

Pyrophosphate mimetics: Inhibition of L-fucose biosynthesis to prevent cancer metastasis
Michael Burkart
Department of Chemistry and Biochemistry, UC San Diego

Chemosensitivity of 5-fluorouracil by DNA mismatch repair
John Carethers
Department of Medicine, UC San Diego

Enhancing cancer cell apoptosis by in situ cross-linking of antibodies
Xi Chen
Department of Chemistry, UC Davis

Functional significance of Bmi-1 in human gastric cancer pathogenesis
Xin Chen
Department of Biopharmaceutical Sciences, UC San Francisco

Protein microarrays with SPR detection for serum tumor markers of colorectal cancer
Quan Cheng
Department of Chemistry, UC Riverside

Understanding structural consequences of p53 cancer mutations and the mechanism of functional rescue using NMR spectroscopy
Melanie Cocco
Department of Molecular Biology and Biochemistry, UC Irvine

Identifying novel anti-tumor agents by caspase activation
Andrew Fisher
Section of Molecular and Cellular Biology, UC Davis

Mechanical contributions to leukostasis in leukemia
Daniel Fletcher
Department of Bioengineering, UC Berkeley

Structure and dynamics of ErbB receptors: 2D IR studies of the Neu transmembrane domain in lipid bilayers
Nien-Hui Ge
Department of Chemistry, UC Irvine

E-cadherin mediated signaling in differentiation and proliferation
Colin Jamora
Section of Cell and Developmental Biology, UC San Diego

Establishing a comprehensive structural analysis of spliceosome components
Melissa Jurica
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz

Hepatitis C virus RNA dependent RNA polymerase: Structure-function in vitro analysis
Caroline Kane
Department of Molecular and Cell Biology, UC Berkeley

Mechanism of fidgetin function during cell division
Francis McNally
Section of Molecular and Cellular Biology, UC Davis

Radioprotectant actions of PPAR-gamma agonist pioglitazone for brain radiosurgery
William Melega
Department of Molecular and Medical Pharmacology, UC Los Angeles

Differentiation of gastrointestinal carcinoid tumors
Eric Nakakura
Department of Surgery, UC San Francisco

Roles of unfolded protein response during the hematopoietic stem cell development
Maho Niwa
Section of Molecular Biology, UC San Diego

The role of annexins in modulating protein composition of plasma membrane microdomains in prostate cancer
David Ornstein
Department of Urology, UC Irvine

Synthesis of the telomerase inhibitors brazilide and brazilin using novel chemical methods
Thomas Pettus
Department of Chemistry and Biochemistry, UC Santa Barbara

Targeting Ras/Rho signaling with prenylation inhibitors in myeloid malignancies
Renate Pilz
Department of Medicine, UC San Diego

Characterization of a novel member of the tubulin superfamily
Joseph Pogliano
Section of Molecular Biology, UC San Diego

Understanding the role of rapamycin-sensitive TOR signaling within the mevalonate biosynthetic pathway
Edmund Powers
Section of Molecular and Cellular Biology, UC Davis

Regulation of centrosome maturation in C. elegans
Lesilee Rose
Section of Molecular and Cellular Biology, UC Davis

A mouse model for hepatoblastoma inducible by Wnt 1 expression
Boris Ruebner
Center for Comparative Medicine, UC Davis

Characterization of regulation of the vacuolar ATPase
Martin Sagermann
Department of Chemistry and Biochemistry, UC Santa Barbara

Regulation of the arsenate respiratory reduction pathway in bacteria
Chad Saltikov
Department of Environmental Toxicology, UC Santa Cruz

A unified strategy for access to dihydrooxepins and application to the synthesis of the epidithiapiperazinedione antitumor natural product MPC1001
Richmond Sarpong
Department of Chemistry, UC Berkeley

The role of UNC-83 in linking the nucleus to the cytoskeleton during nuclear migration
Daniel Starr
Section of Molecular and Cellular Biology, UC Davis

Glycosylated tetracycline: Biosynthesis of hybrid antitumor polyketides using rationally designed metabolic pathways
Yi Tang
Department of Chemical Engineering, UC Los Angeles

Biomarkers of response to mTOR inhibitors in kidney cancer
George Thomas
Department of Pathology and Laboratory Medicine, UC Los Angeles

Biosynthesis of anticancer polyketide natural products guided by structures of polyketide synthase
Shiou-Chuan Tsai
Department of Molecular Biology and Biochemistry, UC Irvine

Conducting polymer nanowire sensors for detection of cancer marker - CEA
Hsian-Rong Tseng
Department of Molecular and Medical Pharmacology, UC Los Angeles

Genome-wide screen for new regulators of TGF-beta signaling
Rahul Warrior
Department of Developmental and Cell Biology, UC Irvine

The predictive value of coagulation markers in identifying patients with cancer at high risk for venous thromboembolism (VTE) during chemotherapy
Ted Wun
Department of Internal Medicine, UC Davis

Using U1 snRNA suppressors to correct splice site defects
Alan Zahler
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz