Updated October 2007

Grants Awarded for the 2007-2008 Award Year

Lysophosphatidic acid regulates mitogenic signaling through P2Y5 activation in prostate cancer cells
Gregory Aponte
Department of Nutritional Sciences and Toxicology, UC Berkeley

Epigenetic interactors in APL tumorigenesis
Robert Blelloch
Department of Urology, UC San Francisco

Targeting Bcl-2 and Tor to induce autophagic cell death in cancer cells
Carrie Brachmann
Department of Developmental and Cell Biology, UC Irvine

Tumor recognition by the innate immune system
Jack Bui
Department of Pathology, UC San Diego

De novo basal body assembly in Naegleria gruberi
Zacheus Cande
Department of Molecular and Cell Biology, UC Berkeley

Establishing human interferon-producing killer dendritic cells (IKDCs) in humanized mouse models: Development of effective immunotherapies for cancers
Camie Chan
Department of Cell Biology and Human Anatomy, UC Davis

Role of heparan sulfate in the pathogenesis of cancer-associated herpesviruses
Laurent Coscoy
Department of Molecular and Cell Biology, UC Berkeley

Autophagy and cell survival during human mammary epithelial cell agonescence
Jayanta Debnath
Department of Pathology, UC San Francisco

Down-regulation of nutrient transporters as a mechanism for tumor suppression by PKC delta
Aimee Edinger
Department of Developmental and Cell Biology, UC Irvine

Mechanisms underlying the failure of checkpoint activation in the C. elegans male germ line
JoAnne Engebrecht
Section of Molecular and Cellular Biology, UC Davis

Characterizing effective counseling regarding colorectal cancer screening
Joshua Fenton
Department of Family and Community Medicine, UC Davis

Thyroid releasing hormone receptor; a novel target for melanoma chemotherapy
Anand Ganesan
Department of Dermatology, UC Irvine

The role of MKL1 in megakaryocyte differentiation and the development of leukemia
Amy Geddis
Department of Pediatrics, UC San Diego

Augmenting anti-tumor immunity with novel cytokine complexes
Ananda Goldrath
Section of Molecular Biology, UC San Diego

Role of the candidate breast tumor suppressor Mage-d1 in mammary gland development
Lindsay Hinck
Department of Molecular, Cell and Developmental Biology, UC Santa Cruz

Engineering transferrin for cancer therapy
Daniel Kamei
Department of Bioengineering, UC Los Angeles

Analysis of emperor's thumbs' homologues USP36 and USP42 in mouse and zebrafish
Frank Laski
Department of Molecular, Cell and Developmental Biology, UC Los Angeles

Cell-based neovascularization to treat irradiated bone defects
Jonathan Leach
Department of Biomedical Engineering, UC Davis

Role of S-nitroso-glutathione reductase in protection against carcinogenic N-nitrosamines
Limin Liu
Department of Microbiology and Immunology, UC San Francisco

Exploring novel pathways in PP2A B56g3 mediated tumor suppression
Xuan Liu
Department of Biochemistry, UC Riverside

Multimodality quantum dots for molecular imaging of cancer
Angelique Louie
Department of Biomedical Engineering, UC Davis

Analysis of CXCL16/CXCR6 in T cell migration and development
Jennifer Manilay
Program of Biological Sciences, UC Merced

Solid-state NMR investigation of the metastasis-inducing protein matrilysin
Rachel Martin
Department of Chemistry, UC Irvine

Notch regulation of cell fate decisions in the mammary gland
Maria Pallavicini
Program of Biological Sciences, UC Merced

Optimization of bladder cancer-specific ligands
Chong-xian Pan
Department of Internal Medicine, UC Davis

Anti-CD20 IgE for the therapy of B-cell lymphomas
Manuel Penichet
Department of Surgery, UC Los Angeles

Nano-virus electrodes for the sensitive and selective detection of prostate-specific membrane antigen in urine
Reginald Penner
Department of Chemistry, UC Irvine

Synthesis and evaluation of the extremophile natural product berkelic acid and its derivatives: Developing selective inhibitors of OVCAR-3 and Matrix metalloproteinases
Thomas Pettus
Department of Chemistry and Biochemistry, UC Santa Barbara

Reactivation of the inactive X chromosome in adult stem cells and breast cancer
Kathrin Plath
Department of Biological Chemistry, UC Los Angeles

Regulation of sphingolipid signaling and biosynthesis by Target Of Rapamycin Complex 2 (TORC2)
Edmund Powers
Section of Molecular and Cellular Biology, UC Davis

Elucidation of molecular mechanisms inactivating the retinoblastoma tumor suppressor protein
Seth Rubin
Department of Chemistry and Biochemistry, UC Santa Cruz

Protein-viral RNA interactions and IRES-mediated translation in EBV-associated malignancies
Ingrid Ruf
Department of Molecular Biology and Biochemistry, UC Irvine

Circadian control of cancer: A molecular link
Paolo Sassone-Corsi
Department of Pharmacology, UC Irvine

Inflammatory reporters of tumorigenesis: Macrophage integrins
Scott Simon
Department of Biomedical Engineering, UC Davis

LEF-1 translation in chronic myelogenous leukemia
Marian Waterman
Department of Microbiology and Molecular Genetics, UC Irvine

Analysis of the Ran pathway in mitosis using a novel small molecule inhibitor
Karsten Weis
Department of Molecular and Cell Biology, UC Berkeley

Functions of an actin nucleating protein that interacts with the transcriptional coactivator p300 and the tumor suppressor p53
Matthew Welch
Department of Molecular and Cell Biology, UC Berkeley

Regulation of N-cadherin-mediated cell-cell adhesion in invasion of malignant cells
Soichiro Yamada
Department of Biomedical Engineering, UC Davis

Sprouty2 loss in melanoma pathogenesis
Benjamin Yu
Department of Medicine, UC San Diego